Meissner's Corpuscle

This video depicts a rotating view of a Meissner's corpuscle in a 60 μm thick section of a human skin punch biopsy from the fingertip. Meissner's corpuscles are located in the dermal papillae beneath the epidermis and detect light touch. They are innervated by 1 or more myelinated nerve axons which become unmyelinated within the corpuscle, as well as by other unmyelinated axons. The axons are detected by immunofluorescence staining for the axonal marker, PGP9.5 (red). The myelin sheath around myelinated axons is visualized by co-staining for myelin basic protein, MBP (green). This video was generated through the Olympus Fluoview FV10i confocal laser scanning microscope system (click HERE for more information) in the research laboratory at Therapath, a neuropathology company specializing in nerve analysis.