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Interpretation of Results
| Interpretation of Results |
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The Epidermal Nerve Fiber Density is determined by enumerating the nerve fibers per unit area. Immunostaining with an antibody to the axonal protein, PGP 9.5 is used to visualize the small nerve fibers, and the average number of axons is determined by examining several sections and fields. Results are expressed as the # nerve fibers/mm. A value that is below, or equal to, the 5th percentile of that found in the normal population is considered abnormal, and consistent with a diagnosis of peripheral neuropathy. Values above the 5th percentile are considered to be in the normal range. A normal result does not rule out the diagnosis of neuropathy, especially if the neuropathy is mild, or if the small fibers are spared. Repeat testing could reveal the presence of neuropathy in progressive cases. The diagnosis or treatment of any medical condition is based on the patent’s clinical presentation and results of all laboratory investigations, as interpreted by the physician. Test results are presented quantitatively at the bottom of page 1 of the report. Additional comments made by the pathologist regarding any qualitative changes that may be present, such as axonal swelling, reduced branching, etc., are presented on page 2 of the report. The figures below shows a photomicrograph of skin with normal and reduced epidermal nerve fiber density, respectively.
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