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Reasons for Performing a Skin Biopsy in a Patient with Neuropathy

Diagnosing small fiber neuropathy. To follow progression of the neuropathy and the response to therapy. To provide documentation, for purposes of insurance coverage, to support recommended treatments Confirming the diagnosis of sensory neuropathy in a patient with a compatbile clinical presnetation but normal electrodiagnostic studies. Differentiating between length-dependent neuropathy, ganglionopathy, or multifocal neuropathy. Diagnosing vasculitc neuropathy that also involves the skin. Diagnosing amyloid neuropathy in a patient with amyloid skin deposits.