Therapath Neuropathology

Ophthalmic Pathology

Services are provided by experienced Ophthalmic pathology specialists who are certified by the American Board of Pathology in Anatomic and Neuropathology.

Therapath is equipped with state of the art facilities for immunohistochemical, immunoflourescence, and light microscopy services with access to electron microscopy.

We offer a complete set of available stains for ophthalmic pathology.


Specimen Collection

Ophthalmic tissue specimens are typically submitted in 10% neutral buffered formalin. Specimen containers should be tightly sealed and placed in a biohazard bag for shipping.

Ship the specimen with a completed requisition form to:
Laboratory Services
Therapath
545 W 45th St
New York, NY 10036

Please contact our client services team if you have questions about submitting samples.


Ophthalmic Specimen Examples

1. Gelatinous drop-like corneal dystrophy is characterized by ropy thick amyloid deposits underneath Bowman’s layer and in anterior stroma without accompanying epithelial erosion. It is an autosomal recessive dystrophy with adult age onset. It is caused by genetic defects in keratoepithelin gene (also known as transforming growth factor, beta-induced gene or TGFBI) on chromosome 5.
2. Sebaceous carcinoma is a relatively frequent malignancy of the eyelids. It often arises in meibomian glands but rarely also in glands of Zeis. It is an aggressive malignancy masquerading often times as chalazia delaying the initial diagnosis. Histologically it shows prominent nuclear pleomorphism, frequent mitoses, extensive intercellular bridging, and occasional cells with ample cytoplasm and fatty content (sebaceous differentiation).
3. Oncocytoma of caruncle is a rare nesting tumor of the ocular surface arising in accessory lacrimal glands of caruncle. It is partially cystic and harbors bland epithelial cells with exclusive oncocytic metaplasia. It follows a benign clinical course and surgical excision is curative.
4. Melanocytoma of optic nerve head is composed of polyhedral cells with low nuclear cytoplasmic ratio, smoothly contoured nuclei devoid of mitotic activity, and usually heavily pigmented cytoplasm. The neoplasm is ill demarcated showing feathering edges mimicking invasion (seen here spilling into neighboring optic nerve). It does not have metastatic potential and can be treated by surgery.
5. Normal iris and lens: the image shows pupillary zone of iris displaying anterior border layer, minimally pigmented iris stroma, anterior pigment epithelium with smooth muscle fibers of dilator muscle, and completely pigmented posterior pigment epithelium. Pupillary border of iris shows the sphincter muscle in stroma responsible for pupillary constriction. The lower aspect of image reveals anterior face of normal lens with externally placed lens capsule and internal lens epithelium.
6. Incarcerated iris in perforated corneal wound in this image shows crater like corneal perforation borders with central incarcerated iris obstructing the wound and burgeoning to the external ocular surface. Complete disorganization of anterior chamber elements is readily identifiable.